conjunction with hyperthermia, remains a challenge. To address this outstanding issue, this research project is focused on developing core-shell nanostructures comprising of Fe3O4 and a magnetocaloric particle with significantly enhanced magnetic response. These nanoparticles demonstrate magnetic phase transition temperatures around the desired therapeutic temperature window for cancer treatment (43-45 °C), thereby enabling self-regulation of the heating of the tumor area during hyperthermia treatment. Further, the long range magnetic exchange interaction between the core and shell leads to enhanced and tunable magnetofunctional properties, thus improving contrast in MRIs without needing to increase the static magnetic fields achievable in current commercial MRI set-ups